Why Am I Not Losing Weight on Ozempic®?

You've started using Ozempic® to lose weight, but the results you anticipated — or perhaps were even promised — aren't showing up. Naturally, you're left wondering, "Why am I not losing weight on Ozempic®?" While it's possible that the medication might not be working as expected for unknown reasons, it's important to focus on the factors you can control while figuring things out.

Have you allowed enough time to see the results? Are you pairing the medication with a balanced diet and consistent exercise? Could your lifestyle choices be influencing your progress?

Here, we'll explore why Ozempic® might not deliver the weight loss results you expected. We'll dive into the typical timeline to see results, discuss factors affecting its effectiveness, and provide recommendations for your diet, exercise routine, and lifestyle.

Not Losing Weight on Ozempic®? Here's What to Know

If you're not losing weight as expected while using Ozempic®, it's important to consider a few factors:

• When considering Ozempic® and weight loss, individuals' responses to medications can vary widely. What works for one person might not work the same for another.
• Understand that weight loss medications like Ozempic® are tools, not magic solutions. They are most effective when combined with healthy habits such as proper diet and regular exercise.
• Weight loss is gradual; expecting rapid results can lead to frustration. If you've just started using Ozempic®, you might need to give it more time to see meaningful changes.
• Discuss your experience with your healthcare provider. They can assess the dosage, evaluate other potential causes for your lack of progress, and provide personalized advice. If necessary, they might recommend an alternative treatment or adjust your plan to help you achieve your weight loss goals.

How Does Ozempic Work for Weight Loss?

Ozempic® (semaglutide), originally designed to manage blood sugar in type 2 diabetes, has proven effective for weight loss. [1] It mimics the hormone GLP-1, naturally produced in the gut, and aids in weight loss through several mechanisms:

• Suppresses appetite: Ozempic® reduces hunger by acting on the brain's hunger centers, helping you feel full with less food.
• Slows stomach emptying: It delays stomach emptying, prolongs fullness after meals, and curbs the urge to snack.
• Regulates blood sugar: By improving glucose management, Ozempic® helps prevent cravings triggered by blood sugar spikes and crashes.
• Promotes fat loss: Ozempic® targets explicitly fat loss, preserving muscle mass, which is vital for overall health.

Typical Time It Might Take to Start Seeing Results on GLP-1s

The timeline for seeing results with GLP-1 medications, such as Ozempic®, can vary widely based on factors like your starting weight, metabolism, and adherence to lifestyle changes. Many patients notice weight loss within the first few weeks of treatment, but significant results typically require several months.

Clinical studies indicate that noticeable weight loss with GLP-1s often occurs after 12 to 16 weeks of consistent use. For example, in a 68-week trial, participants taking weekly doses of semaglutide lost an average of 5 to 15 percent of their body weight, with most losing around 15%, or approximately 35 pounds. [2]

Real-world data further supports the efficacy of GLP-1 medications. A study by Dandelion Health, analyzing nearly 17,000 electronic health records from 2019 to 2023, found that participants lost an average of 1.4% of their starting weight after three months, increasing to about 3% after one year. [3]

It's important to remember that individual responses to GLP-1s vary. While some may experience early, rapid weight loss, others might see more gradual results. If you've been on GLP-1s for several months without achieving your desired outcome, consider reassessing your weight loss strategy with your healthcare provider.

Average Ozempic® Results

On average, patients using Ozempic® or similar medications for weight loss can expect to lose around 15-20% of their body weight after a long-term commitment, assuming they also follow a healthy diet and exercise regimen. [4] Clinical trials have shown that some individuals may lose even more, with results sometimes reaching up to 15% of their body weight. [2]

However, you must have realistic expectations and recognize that these averages are just that — averages. Your experience may differ, and that's okay. The key is consistent effort and maintaining a healthy, balanced lifestyle.

Alternate Weight-Loss Medication

If Ozempic® isn't providing the results you need, or if you experience major side effects, alternative medications might be more effective. Other GLP-1 receptor agonists, such as Wegovy® (semaglutide) or Saxenda® (liraglutide), are also used for weight loss and may offer better results for some patients.

Beyond GLP-1s, other weight loss medications include appetite suppressants like phentermine, fat absorption inhibitors like orlistat, and combination medications such as Contrave® (naltrexone/bupropion).

Each medication works differently, so discussing these options with your healthcare provider is essential to finding the best fit for your unique needs.

How Lifestyle Changes Impact Results When on GLP-1s

While medications like Ozempic® can aid in weight loss, they are most effective when paired with healthy lifestyle changes. Your diet, exercise routine, and stress levels affect the medication's effectiveness.

For instance, if you're consuming a high-calorie diet or not getting enough physical activity, you may not see the full benefits of the medication. Likewise, chronic stress can increase cortisol levels, leading to weight gain or impeded weight loss efforts.

A balanced diet rich in whole foods, regular exercise, stress management, and adequate sleep are all essential components of a successful weight loss plan when on GLP-1s.

Exercise Recommendations When on GLP-1s

When using Ozempic® or other GLP-1 medications, incorporating regular exercise into your routine is vital for maximizing weight loss. Combining cardiovascular exercise, strength training, and flexibility exercises might yield positive results.

Cardiovascular Exercise

Aim for at least 150 minutes of moderate-intensity aerobic activity each week. This could include walking, cycling, swimming, or jogging. Cardiovascular exercise helps burn calories and improve heart health.

Strength Training

Incorporate strength training exercises at least two days a week. This could involve free weights, resistance bands, or body-weight exercises like push-ups and squats. Strength training helps build muscle mass, increase metabolism, and reduce weight.

Flexibility and Balance

Remember flexibility and balance exercises, such as yoga or Pilates. These activities improve overall physical health and can help reduce the risk of injury.

Dietary Recommendations When on GLP-1s

Diet is crucial to weight loss, especially when using a medication like Ozempic®. The following dietary recommendations can help you maximize your results.

Focus on Whole Foods

Prioritize whole, unprocessed foods, including plenty of vegetables, fruits, lean proteins, and whole grains. These foods are nutrient-dense and can help you feel full longer.

Limit Sugary and Processed Foods

Reduce your intake of foods high in added sugars and processed ingredients, as these can contribute to weight gain and hinder your progress.

Control Portions

Be mindful of portion sizes, even with healthy foods. Overeating, even nutrient-dense foods, can slow down your weight loss.

Stay Hydrated

Drinking water throughout the day can help you feel full and support overall health. Sometimes, thirst is mistaken for hunger, leading to unnecessary snacking.

Consider a Balanced Approach

Your diet should include a balance of macronutrients (carbohydrates, proteins, and fats). Carbs should come from whole grains and vegetables, lean meats or plant-based proteins, and fats from healthy sources like avocados, nuts, and olive oil.

Weight Care+ Program with Everlywell

If Ozempic® isn't giving you the results you're looking for, or you want additional support on your weight loss journey, consider Everlywell's Weight Care+ program. This program offers personalized access to GLP-1 medications and professional guidance to help you achieve your weight loss goals more effectively.

With Weight Care+, you'll receive ongoing support from healthcare providers and tailored diet, exercise, and lifestyle change recommendations. This approach can help you maximize your weight loss efforts and ensure you're on the right path to a healthier you. Get started with Weight Care+ here.

1. FDA. Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight Loss. Medical Citation URL
2. Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021;384(11):989-1002. Medical Citation URL
3. GLP-1 Real World Efficacy | Dandelion Health Research — Dandelion Health. Dandelion Health. Medical Citation URL
4. The Ozempic Effect: Everything you need to know about medical weight loss. Columbia Surgery. Medical Citation URL.